患有状细胞特征的成年人的慢性病:系统性审查和元分析
Yagahira Castro Sesquen1, Carmela Gelida Barboza Justiniano2, Diego J Aparcana-Granda2
1Howard University, Washington, District of Columbia, United States.
Blood advances
|April 29, 2025
概括
状细胞特征 (SCT) 与患慢性病 (CKD) 和末期病 (ESRD) 的风险更高有关. 这一元分析证实SCT是损伤的重要危险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 状细胞特征 (SCT) 是一种常见的遗传性血液疾病.
- 新出现的证据表明,SCT和慢性病 (CKD) 之间存在潜在的关联.
- 了解这种关联对于风险分层和预防策略至关重要.
研究的目的:
- 进行元分析,确定SCT和CKD之间的关联的统计数据.
- 评估SCT患者中CKD和末期病 (ESRD) 的风险.
- 评估CKD/ESRD患者中SCT的患病率.
主要方法:
- 在PubMed,Embase,全球卫生图书馆和科学网络的系统文献搜索,直到2024年5月.
- 纳入研究报告的几率比率 (OR) 或危险比率 (HR) 的CKD/ESRD在成年人和没有SCT.
- 使用ROBINS-E工具进行偏差风险评估;用于分析的随机效应模型.
主要成果:
- SCT与降低EGFR (OR:1.62) 和蛋白尿 (OR:2.02) 的几率明显更高.
- 降低EGFR和/或蛋白尿的结合结果显示,SCT个体的几率增加 (OR:1.79).
- 在患有ESRD的非洲裔美国人中,SCT的综合流行率为10%,具有很高的异质性.
- 与女性相比,SCT男性的ESRD风险比率较高.
结论:
- 状细胞特征显著增加患慢性病和末期病的风险.
- SCT是损伤的独立危险因素,特别是在男性中.
- 需要进一步的研究来阐明机制,并管理SCT患者的并发症.
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