相关实验视频

Updated: Dec 16, 2025

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

Published on: April 28, 2023

聚多巴胺辅助的双金属离子改造:增强骨质整合和抗菌性能

Jingyang Kang¹, Sikun Meng², Chenhui Liu³

¹Department of Stomatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong 266035, China.

Colloids and surfaces. B, Biointerfaces

|April 29, 2025

概括

用聚多巴胺,铜和离子对植入物表面进行修改,可以增强骨生长并对抗细菌感染. 这种新的涂层提高了植入成功率和患者的治疗结果.

科学领域:

生物材料科学生物材料科学
材料化学材料化学
牙科植入物学牙科植入物学

背景情况:

(Ti) 植入物对于牙置换至关重要,但它们的惰性表面阻碍了骨的整合,并促进了细菌感染.
需要进行表面修改以改善Ti植入物骨质生成和抗菌性质.
目前的战略面临着平衡生物相容性与感染预防的挑战.

研究的目的:

为Ti植入物开发一种新型的表面修饰,使用多多巴胺 (PDA) 添加铜 (Cu) 和 (Ca) 离子.
为了评估修改的Ti表面的骨质生成和抗菌功效.
评估这种双功能涂层在提高Ti植入物性能方面的潜力.

主要方法:

用Cu和Ca离子 (TPDA@CuCa) 合的聚多巴胺涂层Ti表面的制造.
表面湿透,离子释放和蛋白质吸附的材料特征.
对大肠杆菌和黄金杆菌的抗菌活性进行了体外评估.
评估骨质细胞粘附,矿化和基因表达.

主要成果:

TPDA@CuCa涂料表现出极好的表面湿透性和生物相容性.
观察到Cu2+和Ca2+离子持续释放,增强蛋白质吸附和细胞相互作用.
对常见的口腔病原体实现了显著的抗微生物活性.
证实了骨质细胞粘附,矿化和骨质基因表达的增强.

结论:

开发的TPDA@CuCa表面修饰策略有效地增强了植入物的骨质原生和抗菌特性.
这种双功能方法为改善Ti植入物骨整合和降低感染风险提供了一个有希望的解决方案.
进一步的研究可能会验证这种涂层在牙科和骨科手术中的临床应用.

关键词:

抗菌剂抗菌剂抗菌剂生物材料是一种生物材料.骨再生骨的再生聚多巴胺胺是一种多多巴胺.的植入物是一种植入物.

更多相关视频

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

相关概念视频

Metal-Ligand Bonds

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

Complexometric Titration: Ligands

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...