微血管入侵风险的分级影响肝细胞癌患者的存活率,这些患者接受辅助性跨动脉化学栓塞治疗:一项多中心研究
Jin-Pian Lu1, Jin-Kai Feng2, Yang Zhao3
1Department of General Surgery, Dongyang Hospital of Traditional Chinese Medicine, Jinhua, 322100, Zhejiang Province, China.
概括
术后辅助性跨动脉化学栓塞 (PA-TACE) 改善了肝细胞癌 (HCC) 患者的存活率,在肝切除后具有高风险的微血管入侵 (MVI). 对于低风险的MVI病例,不建议使用PA-TACE.
科学领域:
- 肝胆道手术 肝胆道手术
- 干预性瘤学干预性瘤学
- 肝细胞癌研究 肝细胞癌研究
背景情况:
- 微血管侵袭 (MVI) 是肝细胞癌 (HCC) 在肝切除 (LR) 后的一个关键预后因素.
- 术后辅助性跨动脉化学栓塞 (PA-TACE) 在改善MVIHCC患者的治疗结果方面的作用仍在调查中.
研究的目的:
- 为了评估PA-TACE对MVI的HCC患者在LR之后的预后的影响.
- 确定MVI风险分级是否会影响PA-TACE在HCC患者中的疗效.
主要方法:
- 对接受LR的MVIHC患者的回顾性分析,比较PA-TACE和没有PA-TACE的结果.
- 评估了整体存活率 (OS) 和无复发存活率 (RFS).
- 根据MVI风险分级进行了子组分析.
主要成果:
- 与单独LR相比,PA-TACE在整体队列中显著改善了OS和RFS.
- 对于高风险MVI的HCC患者,PA-TACE显著改善了OS和RFS.
- 在低风险MVI的HCC患者中,没有观察到PA-TACE对生存的显著益处.
结论:
- 在患有高风险MVI肝切除后HCC患者中,应选择性考虑PA-TACE.
- 在治疗性肝切除后,不建议PA-TACE用于患有低风险MVI的HCC患者.
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