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暴露对乳腺癌风险的影响:探索剂量反应关系和调解效应

Yongbin Lu¹, Yongxia Dang², Yilin Chen²

¹Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China; Evidence-Based Social Science Research Center, Health Technology Assessment Center, School of Public Health, Lanzhou University, Lanzhou, Gansu, China; Gansu Key Laboratory of Evidence-Based Medicine, Lanzhou, Gansu, China.

Ecotoxicology and environmental safety

|April 29, 2025

概括

暴露与乳腺癌 (BC) 风险增加有关,特别是在雌激素受体阳性 (ER +) 亚型中. 糖化血红蛋白 (HbA1c) 可能会调解这种关联,这表明代谢因素在与相关的BC发展中起着作用.

科学领域:

环境健康环境健康
在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

(Cd) 是一种内分泌干扰物,与像乳腺癌 (BC) 这样的与激素相关的癌症有关.
之前关于Cd暴露和BC风险的研究已经产生了不一致的发现.
对于Cd对特定BC亚型的影响尚不清楚.

研究的目的:

调查暴露与乳腺癌风险之间的关联.
探索和BC亚型之间的关系.
确定潜在的机制,如糖化血红蛋白 (HbA1c),将暴露与BC.联系起来.

主要方法:

后勤回归和限制立方线 (RCS) 用于分析国家健康和营养检查调查 (1999-2020) 的数据.
为了验证这种关联,对20项研究进行了元分析.
调解分析被用来探索潜在的机制.

主要成果:

较高的含量与BC风险的增加显著相关 (OR = 3.74).
在尿和BC风险之间观察到线性剂量反应关系.
分析表明,暴露与BC风险之间存在联系 (RR=1.17),特别是对于雌激素受体阳性 (ER+) 亚型 (RR=1.08).
糖化血红素 (HbA1c) 在与乳腺癌风险相关性中占9.09%.

结论:

暴露可能与乳腺癌风险增加有关,特别是ER+亚型.
糖化血红蛋白 (HbA1c) 在-乳腺癌风险通路中起到调解作用.
这些发现突显了暴露,代谢失调 (HbA1c) 和乳腺癌发展之间的相互作用.

关键词:

乳腺癌乳腺癌乳腺癌是的组成部分.这就是HbA1c.调解效应是一种调解效应.

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