杏仁核岛对中性刺激的反应和焦虑敏感性的潜在预测
Shannon E MacDonald1, Claudia R Becker1, Annmarie MacNamara2
1Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States of America.
Progress in neuro-psychopharmacology & biological psychiatry
|April 29, 2025
概括
焦虑敏感性 (AS) 与大脑对中性刺激的反应加剧有关,预测未来AS的增加. 这表明,对良性线索的过度桃体和胰岛活动可能会先发并增加焦虑症的风险.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 焦虑敏感性 (AS) 是焦虑障碍的一个关键风险因素.
- AS涉及将良性身体感觉视为威胁的感知.
- 大脑成像研究将AS与与威胁相关的区域 (如杏仁体和胰岛) 中的神经活动的改变联系起来.
研究的目的:
- 为了调查桃体岛 (AMYG-INS) 对中性和负面刺激的血氧水平依赖 (BOLD) 反应是否预测未来AS的增加.
- 了解随着时间的推移,AS的发展和维护背后的神经机制.
主要方法:
- 使用fMRI扫描来测量AMYG-INS BOLD对46名参与者的中性和负面图像的反应 (33名具有内化障碍).
- 在基线和1.5年后通过自我报告来评估AS.
- 统计模型检查了基线BOLD响应是否预测了AS的变化.
主要成果:
- 较高的基线AMYG-INS BOLD对中性图像的反应预测在随访时增加AS,即使在对基线AS和对负面图像的反应进行控制之后.
- 在截面上,更大的AMYG-INS激活到负相比中性图像与更高的电流AS相关.
结论:
- 对良性刺激的高AMYG-INS BOLD反应可能会先发并增加患上更高AS的风险.
- 确定的AS与神经模式有关,包括对负面刺激的夸张反应,通常在内化障碍中见到.
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