父母癌症史的患病率和体外受精利用率
Abby L Chen1, Shufeng Li1,2, Valerie L Baker3
1Department of Urology, Stanford University School of Medicine, Stanford, CA, United States.
Journal of the National Cancer Institute
|April 29, 2025
概括
父母癌症史在通过体外受精 (IVF) 怀孕的分娩中比自然怀孕的分娩更为常见. 这种患病率随着时间的推移而增加,强调了对生育服务的需求.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 癌症存活率正在增加,导致更多的人希望在治疗后生孩子.
- 评估通过辅助生殖技术怀孕后代的父母癌症史至关重要.
研究的目的:
- 为了确定通过体外受精 (IVF) 怀孕的出生与自然怀孕的出生中父母癌症史的流行率.
- 分析随着时间的推移与受孕方法相关的父母癌症史的趋势.
主要方法:
- 利用来自助孕生殖技术协会诊所结果报告系统 (2004-2018) 的数据,与纽约,马萨诸塞州和北卡罗来纳州的出生证明和癌症登记处联系在一起.
- 通过试管婴儿构思的分娩与随后自然构思的分娩进行了比较,分析了孩子出生之前的父母癌症诊断.
主要成果:
- 分析了814,658例分娩 (82,544例试管婴儿,732,114例自然分娩).
- 父母癌症史在试管婴儿受孕的分娩中 (1.2%的母亲,1.8%的父亲) 与自然 (0.5%的母亲,0.4%的父亲) 较高.
- 在研究期间,父母癌症史的患病率有所增加,在试管婴儿父母中,特定的癌症类型更频繁.
结论:
- 在所有分娩的1.1%和在体外受精产生的3.0%中,父母中有一个患有癌症的病史.
- 癌症患病率的增加凸显了癌症幸存者瘤生育计划的关键作用.
- 在通过试管婴儿怀孕的父母中,特定的恶性瘤更为普遍.
相关概念视频
01:24In Vitro Fertilization
147
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
147
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
01:28Infertility in Females
184
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
184
01:30Cancer Vaccines
237
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
237
01:25Mutagenicity and Carcinogenicity
1.1K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.1K
01:57Meiosis II
181.4K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
181.4K