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Updated: May 12, 2025

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

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选择性BCL-2抑制剂通过诱导mtDNA释放触发了STING-依赖的抗瘤免疫

Wenxin Zhang1, Xiaohui Pan1, Longsheng Wang1

  • 1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

Journal for immunotherapy of cancer
|April 29, 2025
PubMed
概括

ABT-199通过诱导线粒体DNA释放,增强抗瘤免疫力和与抗PD-L1疗法的协同作用来激活干扰素基因刺激器 (STING) 途径. 这为癌症免疫疗法中的STING激活提供了一个新的小分子.

关键词:
结肠直肠癌 结肠直肠癌是什么细胞因子细胞因子免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.

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