相关实验视频

Updated: May 9, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

[由抗细胞因子自身抗体引起的免疫缺陷和相关感染]

S Q Liang¹, B Cao², Z Y He¹

¹Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

|April 29, 2025

概括

对细胞因子的自身抗体阻断了它们的功能,增加了感染易感性. 本综述涵盖了由抗细胞因子自身抗体引起的疾病,如抗干扰素和抗干扰素抗体.

科学领域:

免疫学免疫学免疫学
病理学病理学病理学

背景情况:

对细胞因子的自身抗体,称为抗细胞因子自身抗体 (AAb),是由血细胞产生的.
这些抗体干扰细胞因子信号通路,阻断基本的生物功能.
这种干扰导致对病原体的敏感性增加,导致复发性和复杂的感染.

研究的目的:

总结由抗细胞因子自身抗体引起的疾病的临床表现.
阐明这些免疫相关疾病的潜在机制.
提供已知抗细胞因子自身抗体及其标的概述.

主要方法:

临床表现和机制的文献综述.
已知抗细胞因子自身抗体的识别和分类.
分析自身抗体对细胞因子功能和宿主防御的影响.

主要成果:

鉴定了针对干扰素,GM-CSF,IL-6,IL-17和IL-12/23的抗细胞因子自身抗体.
确定了这些自身抗体与免疫缺陷相关的感染之间的关联.
详细介绍了受影响患者的临床表现和致病机制.

结论:

反细胞因子自身抗体是由于免疫信号受损而导致复发感染的重要原因.
了解临床特征和机制对于诊断和管理至关重要.
对这些自身抗体的进一步研究可以导致针对免疫缺陷的向治疗.

更多相关视频

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

相关概念视频

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Humoral Immune Responses

Humoral Immune Responses

What is the Immune System?

What is the Immune System?

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...