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增长激素替代疗法在儿童发作的瘤
Laura van Iersel1, Jiska van Schaik1, Hanneke M van Santen2
1Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Pediatrics, Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, the Netherlands.
概括
增长激素替代疗法 (GHRT) 对患有瘤 (cCP) 的儿童至关重要,以改善生长和整体健康. 有证据表明,GHT是安全的,这些患者没有增加瘤进展的风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经瘤学神经瘤学
- 内分泌学 在内分泌学.
背景情况:
- 儿童发作瘤 (cCP) 经常导致由于瘤或其治疗而导致生长激素 (GH) 缺乏.
- 增长激素替代疗法 (GHRT) 对于优化受影响儿童的增长速度和最终身高至关重要.
- 持续GHRT到成年期为代谢,骨,心理健康和生活质量提供了显著的好处.
研究的目的:
- 审查当前关于GH替代疗法 (GHRT) 在儿童瘤 (cCP) 的安全性和疗效的证据.
- 评估GHRT对中枢癌症治疗患者的瘤进展,复发,二次瘤和死亡率的影响.
- 为新诊断的CPT患者提供关于启动GHRT最佳时间的指导.
主要方法:
- 对现有文献和临床证据的系统审查,关于GHRT在cCP.
- 对研究长期结果的分析,包括瘤行为和患者存活率.
- 评估关于GHTR对生长和代谢参数的益处的数据.
主要成果:
- 目前的证据表明,GHRT不会增加瘤进展,复发,二次癌症或心血管癌症患者死亡的风险.
- 早期启动GHRT (早在手术后三个月) 可以有效地解决线性生长缺陷和代谢问题.
- 在CPT幸存者中,GHRT对骨健康,心理健康和整体生活质量产生了积极的影响.
结论:
- 增生激素替代疗法是对患有增生激素缺乏症的脑瘤儿童的安全和有益的治疗方法.
- 应考虑早期启动GHRT,以管理生长和代谢障碍,并有可能长期持续.
- 需要进一步研究早期GHT启动和使用长效GH制剂对心脏病患者的长期影响.
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