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介质干细胞和细胞外囊泡疗法的表观遗传景观

Sha Zhang¹, Zong-Yu Zhang², Bing-Dong Sui³

¹College of Basic Medicine, Shaanxi Key Laboratory of Research on TCM Physical Constitution and Diseases Prevention and Treatment, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China; Department of Traditional Chinese Medicine, The First Affiliated Hospital of Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

Trends in cell biology

|April 29, 2025

概括

介质干细胞 (MSC) 疗法及其细胞外囊泡 (EVs) 利用表观遗传调节来治疗疾病. 本综述探讨了MSC和EV如何重编程受体细胞,为未来的治疗提供了对捐赠者-受体通信的见解.

科学领域:

再生医学是一种再生医学.
免疫学免疫学免疫学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

介酶干细胞 (MSCs) 在组织修复和免疫障碍方面表现有前途.
表观遗传调节对于MSC功能和治疗效果至关重要.
MSCs在表观遗传上影响受体细胞,恢复平衡.

研究的目的:

审查表观遗传调节在MSC和EV疗法中的作用.
了解通过MSCs和EVs调解的细胞间表观遗传重编程.
识别挑战,并激发未来的治疗策略.

主要方法:

对MSC和EV表观遗传机制研究的文献综述.
分析MSC和EV如何转移表观遗传调节剂的分析.
在治疗背景下检查捐赠者-接受者沟通.

主要成果:

MSCs及其衍生的EVs (外体,apoVs) 转移表观遗传因素.
这种转移协调了表观遗传重编程和信号调制.
受体细胞经历表观遗传变化,有助于治疗结果.

结论:

表观遗传调节是MSC和EV治疗疗效的核心.
了解捐赠者-接受者表观遗传通信是推动这些疗法的关键.
未来的研究应该专注于优化表观遗传转移,以改善组织缺陷和疾病的治疗.

关键词:

它们是apoptotic囊泡.表观遗传学是指表观遗传学.细胞外囊泡中的细胞外囊泡.免疫调节免疫调节免疫调节介质细胞干细胞介质细胞干细胞复兴再生是一种再生方式.

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