饮食薄荷醇对寒冷环境中的自主温度调节的影响
Noriyuki Mori1, Masumi Takano1, Aya Nakashima1
1Department of Food Science and Nutrition, Faculty of Human Life, Doshisha Women's College of Liberal Arts.
Journal of nutritional science and vitaminology
|April 29, 2025
概括
低剂量饮食薄荷醇通过激活TRPM8通道来增强小鼠的自主温度调节,改善在寒冷条件下身体温度的控制,而不会影响食物摄入量或体重.
科学领域:
- 生理学 生理学 生理学
- 代谢过程中的代谢.
- 神经科学是一个神经科学.
背景情况:
- 人体温度是由行为和自主机制调节的.
- 短暂受体潜能拉斯8 (TRPM8) 通道对于感知寒冷和温度调节至关重要.
- 薄荷激活TRPM8并促进脂肪细胞色,但其对自主热调节的影响尚不清楚.
研究的目的:
- 研究饮食中的薄荷醇对小鼠自主温度调节的影响.
- 为了确定薄荷醇在寒冷压力下对体温调节的影响.
主要方法:
- 小鼠被食了含有0.25%和0.5%薄荷醇的饮食,持续了2周或4周.
- 测量了体重,食物摄入量,内脏脂肪,直肠温度和间棕色脂肪组织 (IBAT) 温度.
- 在IBAT中分析了TRPM8基因表达.
主要成果:
- 一种0.5%的薄荷醇饮食减少了食物摄入量,体重和内脏脂肪.
- 在4周的0.25%薄荷饮食中,在寒冷中防止了直肠和IBAT温度的下降.
- 低剂量的薄荷醇在IBAT中提高了TRPM8基因表达的调节.
结论:
- 饮食中的薄荷醇,特别是低度的薄荷醇 (0.25%),可以增强自主温度调节.
- 薄荷醇激活TRPM8以改善寒冷耐受性,而不会对食欲或体重产生不良影响.
- 这表明薄荷在温度调节障碍中的潜在治疗作用.
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