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非生殖中心扩散的大B细胞淋巴瘤,源于十二指甲状腺类型卵泡淋巴瘤的共同起源

Tomoyo Kubo¹, Yuya Nagai¹, Yoshimitsu Shimomura¹

¹Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.

Journal of clinical and experimental hematopathology : JCEH

|April 29, 2025

概括

十二指甲型毛囊性淋巴瘤 (DFL) 很少转变为扩散性大B细胞淋巴瘤 (DLBCL). 这个案例显示DFL转化为非生殖中心DLBCL,突出显示了长期患者监测的必要性.

科学领域:

血液学血液学血液学
在瘤学瘤学.
病理学病理学病理学

背景情况:

十二指甲型毛囊性淋巴瘤 (DFL) 是一种罕见的毛囊性淋巴瘤 (FL) 的惰性亚型.
DFL的组织学转化为扩散性大B细胞淋巴瘤 (DLBCL) 是不常见的,并且不太了解.
了解DFL转变的临床病理和生物特征对于患者管理至关重要.

研究的目的:

描述一个罕见的DFL转变为非生殖中心DLBCL的案例.
通过综合分析,阐明这种转变的生物特征.
强调DFL患者长期随访的重要性.

主要方法:

进行了免疫组织化学,细胞遗传学 (FISH) 和分子 (PCR,测序) 分析.
诊断证实了DFL和转变的DLBCL.
审查了包括患者病史,治疗和结果在内的临床数据.

主要成果:

一名62岁的女性患有DFL,6年后发生了性乳房病变.
活检显示DLBCL具有非生殖中心B细胞 (非GCB) 免疫表型,这对于转变的FL来说是不寻常的发现.
基因分析证实了DFL和DLBCL的共同克隆起源,其中BCL6转位存在于两者之间.

结论:

DFL可以转化为非GCB DLBCL,需要警的长期监控.
这个案例提供了对DFL转换的分子机制的洞察.
通过手术和R-CHOP化疗的成功治疗导致了为期3年的完全缓解.

关键词:

克隆关系克隆关系十二指甲类型的毛囊性淋巴瘤非生殖中心的B细胞免疫表型.聚合酶连锁反应的发生.转化转化转化转化转化转化转化转化

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