相关实验视频

Updated: May 9, 2025

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

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RAB22A/TMEM33/RTN4组件启动了一个分泌ER-phagy通路

Xueping Zheng1, Dongmei Fang1, Hao Shan1

  • 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, China.

Cell discovery
|April 29, 2025
PubMed
概括

研究人员发现了一种新的分泌ER-phagy通路. 这一过程涉及RAB22A,TMEM33和RTN4蛋白质,导致细胞外囊泡 (R-EVs) 的形成和分泌,通过一种称为Rafeesome的过程.

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相关概念视频

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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Tail-anchoring of Proteins in the ER Membrane

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