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Updated: May 9, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

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通过UHRF1-介导的表观遗传重编程调节糖解,促进B细胞急性淋巴细胞白血病的进展

Yan Huang1, Luting Luo1,2,3, Yangqi Xu1

  • 1Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China.

Cell death & disease
|April 29, 2025
PubMed
概括

这项研究确定含有PHD和RING手指域1 (UHRF1) 的乌比奎丁类药物是复发性B细胞急性淋巴细胞白血病的关键驱动因素. 用UM164针对UHRF1显示出通过抑制癌细胞生长和促进细胞亡来改善预后的希望.

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