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Updated: May 9, 2025

Methodology for Accurate Detection of Mitochondrial DNA Methylation
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Published on: May 20, 2018

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线粒体膜超极化调节核DNA甲基化和基因表达通过脂重塑

Mateus Prates Mori1, Oswaldo A Lozoya2, Ashley M Brooks3

  • 1Mechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Durham, NC, USA.

Nature communications
|April 29, 2025
PubMed
概括

线粒体超极化,或增加的膜潜力,导致核DNA高甲基化,并改变基因转录. 这种与脂重塑相关的表观遗传变化会影响细胞功能和疾病.

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