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通过BMP-2 mRNA转移的BMSCs促进了高级骨再生

Theeraphat Surisaeng1,2, Wichaya Wisitrasameewong3,4, Chantrakorn Champaiboon1,2

  • 1Center of Excellence in Periodontal Disease and Dental Implant, and Immunology Research Center, Chulalongkorn University, Bangkok, Thailand.

Scientific reports
|April 29, 2025
PubMed
概括

编码骨形态蛋白-2 (BMP-2) 的信使RNA (mRNA) 有效地提高了关键尺寸缺陷中的骨再生. 直接应用或通过感染细胞输送显示了对面骨修复的希望.

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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...