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格里森模式4和2级前列腺癌患者的积极监测

Alessandro Uleri¹, Michael Baboudjian², Riccardo Leni^3,4

¹Department of Urology, North Hospital, Aix-Marseille University, APHM, Marseille, France.

Prostate cancer and prostatic diseases

|April 29, 2025

概括

对于2级前列腺癌 (PCa) 的积极监测 (AS) 即使超过10%的模式4也是可行的. 活检的基线模式4没有预测这个队列的升级或治疗需求.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
病理学病理学病理学

背景情况:

积极监测 (AS) 是低风险前列腺癌 (PCa) 的管理策略.
在指导AS决定中,生物检查的基线模式4百分比对于Grade Group 2 (GG2) PCa的作用需要进一步澄清.

研究的目的:

根据图像导向活检中识别的第4个模式的初始数量,评估GG2PCa患者的AS结果.

主要方法:

在10个欧洲中心对104名GG2PCa患者进行了回顾性分析,这些患者患有AS.
使用统计相关性和多变量考克斯回归分析来评估模式4百分比与临床结果之间的关联.

主要成果:

模式4的中位数为10% (范围为5-40%).
在模式4的百分比和确认活检上的升级或降级之间没有发现统计学意义上的相关性.
模式4的百分比与GG3升级或在33个月的中位随访期间需要确定的治疗无关.

结论:

患有GG2 PCa和基线模式4百分比大于10%的患者不应自动排除在AS之外.
在决定GG2PCa的AS时,应考虑有利的临床参数以及模式4百分比.

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