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Updated: May 9, 2025

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
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GIPR-Ab/GLP-1-抗体结合剂需要大脑GIPR和GLP-1R来增加肥胖小鼠的体重减轻

Clarissa M Liu1,2, Elizabeth A Killion1, Rola Hammoud3

  • 1Department of Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA.

Nature metabolism
|April 29, 2025
PubMed
概括

中枢神经系统 (CNS) GIPR和GLP-1R信号传递对于双重GIPR阻断/GLP-1R激活抗体结合物的减肥效果至关重要. 这两种受体对于最大限度地提高肥胖治疗结果至关重要.

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