在炎症性肠病患者中H.Pylori的患病率及其与严重程度的关联
Abdullah D Alotaibi1,2, Abdullah A Al-Abdulwahab3,4, Mona H Ismail3,4
1Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal university, Dammam, Eastern Province, Saudi Arabia. adotaibi@iau.edu.sa.
BMC gastroenterology
|April 29, 2025
概括
在炎症性肠道疾病 (IBD) 患者中,Helicobacter pylori (H. pylori) 感染比健康个体少. 吸烟和自身免疫性疾病与H. pylori有关,但与疾病严重程度无关.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 杆菌 (H. pylori) 和炎症性肠病 (IBD) 之间的关系是正在进行的胃肠病学研究领域.
- 之前的研究已经产生了关于IBD患者的H. pylori患病率及其对疾病结果的影响不一致的结果.
研究的目的:
- 在被诊断患有炎症性肠病 (IBD) 的患者中调查H. pylori感染的患病率.
- 确定H. pylori感染与IBD的严重程度之间的关联,特别是克罗恩病 (CD) 和性结肠炎 (UC).
主要方法:
- 进行了一项前性队列研究,涉及360名参与者,分为IBD组和对照组.
- IBD组进一步分为克罗恩病 (CD) 和性结肠炎 (UC) 队列.
- 在IBD和对照组之间,以及在子组内,比较了H. pylori感染的发病率和疾病严重程度.
主要成果:
- 在对照组 (23.3%) 中,H. pylori感染的发生率明显高于性结肠炎 (UC) 患者 (13.2%).
- H. pylori 感染与吸烟 (p < 0.0001) 和自身免疫性疾病 (16.4%) 的存在有显著的关联.
- 没有观察到H. pylori感染和CD或UC的严重程度之间,也没有与药物的使用有显著的关联.
结论:
- 与一般人群相比,H. pylori感染在炎症性肠病 (IBD) 患者中不太普遍.
- 吸烟和自身免疫性疾病与H. pylori感染有显著的关联.
- 杆菌感染似乎不会影响克罗恩氏病或性结肠炎的严重程度.
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