后COVID-19状态的短期和长期轨迹:来自EuCARE POSTCOVID研究的结果
Andrea Santoro1, Francesca Bai1, Maria Francesca Greco1
1Department of Health Sciences, Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo E Carlo, University of Milan, Milan, Italy.
BMC infectious diseases
|April 29, 2025
概括
后COVID-19状况 (PCC) 影响了许多患者,疲劳和脑雾等症状持续长期. 早期的流行性感染与持久性PCC的更高风险有关.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 后COVID-19状况 (PCC) 影响10-40%的个人在SARS-CoV-2感染后,症状持续数月.
- 了解PCC轨迹和相关因素对于患者管理至关重要.
研究的目的:
- 调查PCC症状的长期发展轨迹,并确定与PCC持续性相关的因素.
- 分析PCC临床表型的随时间变化.
主要方法:
- 从2020年2月到2023年6月,对853名患者 (住院和门诊) 进行了随访.
- 收集的数据包括WHO病例报告表,症状,医院焦虑和抑郁量表 (HADS) 和PTSD查.
- 统计分析包括奇平方,曼-惠特尼,克鲁斯卡尔-瓦利斯测试和后勤回归.
主要成果:
- 在感染后3个月的64.6%,在7个月的36.4%,在26个月的30.4%中存在PCC.
- 常见的PCC表型包括疲劳,呼吸系统问题,脑雾和慢性疼痛;随着时间的推移,阿诺斯米亚/失灵症减少.
- 与持续性相关的因素包括女性性别,早期感染 (2020年),更长时间住院和缺乏疫苗接种. 焦虑,抑郁和PTSD在PCC患者中更为普遍.
结论:
- 7个月后观察到PCC负担显著减少,但三分之一的患者有长期症状.
- 疲劳,呼吸道症状,脑雾和慢性疼痛仍然是PCC的主要临床表现.
- 在流行病早期阶段 (2020年) 感染与持续的PCC独立相关.
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