怀孕期间二手烟暴露与4岁后代左心室结构和功能的关联:前性出生队列研究
Bo Wang1,2, Yongxuan Peng1, Hualin Wang1
1Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
BMC pregnancy and childbirth
|April 29, 2025
概括
孕妇在怀孕期间接触二手烟与儿童心脏尺寸的改变有关. 怀孕早期的暴露与左心室大小增加有显著的关联,这表明潜在的长期心血管风险.
科学领域:
- 心血管科学 心血管科学
- 环境健康 环境健康
- 儿童心脏病学 儿童心脏病学
背景情况:
- 怀孕期间二手烟 (SHS) 对后代心脏发育的影响尚未完全理解.
- 这项研究调查了孕期母亲SHS暴露与儿童心脏结构和功能之间的关系.
研究的目的:
- 确定怀孕期间母亲被动吸烟与后代心脏变化之间的相关性.
- 评估SHS暴露对幼儿时期左心室 (LV) 维度和功能的影响.
主要方法:
- 来自上海出生队伍的1089对母子对被分析.
- 在怀孕期间收集了SHS暴露数据和基线特征.
- 在4岁的儿童身上进行了心声评估.
- 用多个线性回归模型来评估关联.
主要成果:
- 怀孕期间的SHS暴露与子女的腹痛和腹痛内径增加有关.
- 怀孕早期 (≤12周) 的母亲被动吸烟与 LV 尺寸,包括终端透析和终端静脉体积,有积极的关联.
- 在SHS暴露和LV功能之间没有发现显著的关联.
结论:
- 孕期SHS暴露与子女LV尺寸的亚临床变化相关,特别是在怀孕早期.
- 需要进一步的研究来证实这些发现,并调查长期的心血管影响.
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