人类乳头瘤病毒 (HPV) 介导的癌症:一个有洞察力的更新
Sadaf Khursheed Baba1, Shahad Shahdad Eissa Alblooshi2, Reem Yaqoob1
1Department of Chemistry, College of Science (COS), United Arab Emirates University (UAEU), P.O. Box 15551, Al Ain, United Arab Emirates.
人类乳头瘤病毒 (HPV) 通过通过E6和E7coproteins改变细胞周期,导致多种癌症. 本综述涵盖了HPV癌症生物学,流行病学以及监测治疗反应的新生物标志物策略.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 分子生物学分子生物学
背景情况:
- 人类乳头瘤病毒 (HPV) 是导致宫癌,门癌和头癌的重要原因.
- 持续的HPV感染和特定的高风险基因型 (例如HPV-16,HPV-18) 驱动瘤发生.
- HPV 的 E6 和 E7 coproteins 破坏细胞循环调节,抑制细胞亡,并促进 DNA 损伤.
研究的目的:
- 为提供最近HPV相关癌症生物学和流行病学进展的全面概述.
- 要突出HPV驱动的致癌的分子途径,专注于coprotein的角色.
- 讨论当前的诊断,治疗策略和新兴的生物标志物应用.
主要方法:
- 关于HPV和相关癌症的最新科学出版物的文献综述.
- 分析涉及HPVcoproteins (E6,E7) 和宿主细胞相互作用的分子机制.
- 综合流行病学数据和诊断和治疗方法的进展.
主要成果:
- HPV-16和HPV-18与超过70%的宫癌和其他恶性瘤有关.
- 病毒瘤蛋白E6和E7是细胞转化的关键驱动因素.
- 生物标记物 (mRNAs,miRNAs,lncRNAs,蛋白质,遗传标记物) 在监测治疗反应方面表现有前途.
结论:
- 尽管疫苗接种和治疗方面取得了进展,但HPV仍然是一个重大的全球卫生挑战,需要继续进行研究.
- 了解HPV分子通路对于开发有效的癌症控制策略至关重要.
- 基于生物标志物的监测为个性化癌症治疗和管理提供了新的途径.
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