用Tc-99m Sestamibi进行的分子乳房成像可以安全排除病理乳头泄漏中的恶性病变吗?
Sofia C Vaz1,2, Christinne L S Corion3, Jelle Goeman4
1Nuclear Medicine-Radiopharmacology, Champalimaud Clinical Center, Champalimaud Foundation, Lisbon, Portugal.
分子乳腺成像 (MBI) 改善了乳腺癌 (BC) 的检测在患有病态乳头泄漏 (PND) 和负面或不确定的常规诊断 (CD) 成像的患者. MBI提供了更高的灵敏度和负预测值,有助于准确诊断和防止不必要的程序.
科学领域:
- 放射学和成像学 放射学和成像学
- 在瘤学瘤学.
- 乳腺健康 乳腺健康
背景情况:
- 病态乳头泄漏 (PND) 是一种常见的乳腺疾病,需要排除恶性瘤.
- 传统的诊断 (CD) 影像,包括乳房影像和超声波,是标准的初始评估.
- 分子乳房成像 (MBI) 为评估PND提供了一个潜在的替代或补充工具.
研究的目的:
- 评估MBI在识别乳腺癌 (BC) 中的诊断作用.
- 在传统诊断 (CD) 影像产生负面或不确定的结果的情况下,评估MBI的有效性.
- 为了比较MBI与PND的CD成像的性能.
主要方法:
- 进行了一项回顾性,单中心的队列研究.
- 包括2012年至2020年期间通过CD成像和MBI评估的PND患者.
- 病理学报告是诊断的黄金标准;对于没有病理学的病例,使用后续检查.
主要成果:
- 在96例PND病例中,18例 (20%) 被诊断为乳腺癌 (BC).
- 在仅仅通过CD成像检测错过的病例中,MBI检测到了BC,突出了其补充价值.
- 与CD成像相比,MBI显示出更高的灵敏度 (83%与33%) 和负预测值 (96%与86%).
结论:
- 分子乳腺成像 (MBI) 显示出显著的诊断准确性检测乳腺癌 (BC) 在患有PND的患者.
- 当常规诊断 (CD) 成像结果是负面或不确定的时,MBI特别有价值.
- 研究结果表明,MBI可以通过提高诊断确定性来帮助预防不必要的外科手术.
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