代谢综合征和胰岛素耐药与减弱的执行功能的联系 预兆后:一个嵌套的病例对照研究
Robert-Jan Alers1,2, Chahinda Ghossein-Doha2,3, Yentl Brandt4,5
1Department of Obstetrics and Gynaecology, Maastricht University Medical Centre+ (MUMC+), Maastricht, the Netherlands.
孕前可以导致持久的执行功能问题. 代谢综合征和胰岛素抵抗与怀孕后几年的女性的这些认知缺陷有关.
科学领域:
- 产科和妇科 产科和妇科
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 孕前是一种与长期孕产妇认知障碍相关的妊娠并发症,特别影响执行功能.
- 执行功能对于目标导向行为至关重要,在代谢综合征和胰岛素抵抗中也出现了类似的缺陷.
研究的目的:
- 调查执行功能与代谢综合征,其组成部分,以及有先兆子史的妇女的胰岛素抵抗之间的关联.
主要方法:
- 一个嵌套的病例控制研究与女性进行了0.5到30年后的孕前.
- 执行功能被评估使用行为评级成年人执行功能的库存.
- 代谢综合征和胰岛素耐药性是根据既定的标准 (NCEP ATP III和HOMA-IR) 定义的.
主要成果:
- 减弱的执行功能与代谢综合征 (OR 4.20),高血糖症 (OR 2.96) 和肥胖症 (OR 3.86) 有关.
- 较高的胰岛素抵抗 (HOMA-IR) 与执行功能受损 (OR 7.26) 有着强烈的联系.
- 代谢综合征占执行功能障碍可归因部分的13%,胰岛素抵抗占56%.
结论:
- 代谢综合征和胰岛素抵抗显着与孕前后妇女执行功能下降有关.
- 这些发现表明,干预措施的潜在目标是改善前前后妇女的认知结果.
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