血清和精液维生素D水平和精子参数之间的关联
Goksun Ipek1, Sezcan Mumusoglu2, Gurkan Bozdag3
1Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara Bilkent City Hospital, Ankara, Turkey.
The journal of obstetrics and gynaecology research
|April 30, 2025
概括
正常的血清维生素D水平与更好的精子质量有关,包括运动性和形态学. 然而,维生素D对精子功能的直接影响可能是由细胞内介导的,而不是直接由精子维生素D或抗氧化剂水平.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养生物化学 营养生物化学
- 精子生物学 精子生物学
背景情况:
- 维生素D在各种生理过程中起作用,包括生殖健康.
- 维生素D对人类精子参数和运动性的特定影响需要进一步阐明.
- 研究维生素D,细胞内和精子中氧化应激之间的相互作用至关重要.
研究的目的:
- 调查血清/精液中维生素D水平与精子参数之间的关联.
- 探索维生素D通过精子细胞内对精子运动的潜在影响.
- 通过测量麦隆迪甲基 (MDA) 来评估维生素D的抗氧化作用.
主要方法:
- 对87名男性患者进行前性研究,根据血清维生素D水平 (低,正常,高) 分类.
- 评价精子特征,包括运动性和形态.
- 使用LC-MS/MS,HPLC和光板阅读器测量精液血维生素D,细胞内和MDA.
主要成果:
- 正常的血清维生素D水平与更高的总进步运动精子度和正常的精子形态相关.
- 血清维生素D和精子维生素D,MDA或细胞内水平之间没有发现显著的相关性.
- 精液细胞内水平与精子的总和渐进性运动有正相关.
结论:
- 血清维生素D水平与精子度和形态学有关.
- 血清维生素D与精子维生素D,MDA或细胞内没有直接相关.
- 细胞内是调节精子运动的关键因素,这表明维生素D可能有间接作用.
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