亚洲估计膜过率 (eGFR) 方程的性能评估:系统性审查
A Siddiqui1, S Lakhani1, F A Khan2
1The Aga Khan University, Medical College, Karachi, Pakistan.
The Malaysian journal of pathology
|April 30, 2025
概括
在亚洲人群中,对功能进行准确的评估至关重要. CKD-Epi-Pak 和 CKD-Epi-2021 方程对分别在南亚和东亚估计膜过率 (GFR) 有希望.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 慢性病 (CKD) 是一个重要的全球健康问题.
- 准确评估功能对于及时干预CKD至关重要.
- 淋巴膜过率 (GFR) 是功能的一个关键指标,估计的GFR (eGFR) 方程为传统方法提供了替代方案.
研究的目的:
- 评估各种估计GFR (eGFR) 方程的性能,以准确评估功能.
- 在不同亚洲人群中比较基于肌素和基于酸的方程.
- 为了确定不同亚洲次区域最准确的eGFR方程.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 包括1991年至2023年间发表的研究,涉及成人亚洲人群 (健康或患有CKD).
- 提取了研究细节,人口特征,疾病状况和公式的数据,并使用QUADAS-2工具评估了质量.
主要成果:
- 在南亚,CKD-Epi-Pak在eGFR估计方面表现出卓越的准确性,超过了传统的MDRD方程.
- 在东亚,CKD-Epi-2021公式显示出最佳准确性,而简化的MDRD和修改的盖茨方法显示出低于最佳的性能.
- 在不同亚洲次区域中观察到方程表现的显著差异.
结论:
- CKD-Epi-Pak和CKD-Epi-2021方程显示,在南亚和东亚人群中,分别具有临床实用性的潜力.
- 需要进一步的研究来开发特定于种族的eGFR方程,以提高亚洲人群的准确性.
- 提高eGFR估计的准确性可以导致在不同种族群体中更好地临床管理慢性瘤.
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