含有来自H9N2的内部基因的H5N6病毒表现出增强的致病性和传染性
Manlin He1,2, Lina Liu1,3, Jinglei Hu1,4
1Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Transboundary and emerging diseases
|April 30, 2025
概括
重组H5N6禽流感病毒 (AIV) 呈现出多种风险. 一种带有H9N2内部基因的H5N6 AIV (112) 比另一种更具有病原性和易传播 (125),对人类健康构成更大的威胁.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 禽流感病毒 (AIV) 的重组产生多种H5N6菌株.
- 不同的H5N6 AIV复合物的公共卫生风险尚不清楚.
研究的目的:
- 为了比较从中分离的两个不同的H5N6 AIVs的受体结合,致病性和传染性.
- 评估这些H5N6 AIV复合物对人类健康的潜在威胁.
主要方法:
- 来自的两个H5N6 AIV菌株 (112和125) 的隔离和特征.
- 对禽类和人类类酸受体的病毒受体结合 afinities 的分析.
- 在小鼠模型中评估病原性和传染性,包括直接接触和气溶传播研究.
主要成果:
- 这两种H5N6 AIVs (112和125) 都与鸟类 (α-2,3) 和人类 (α-2,6) 酸受体结合.
- 与H5N6 AIV 125.5相比,H5N6 AIV 112在小鼠中表现出明显更高的致病性和传染性 (包括气溶).
- 感染112的小鼠表现出快速的体重减轻和死亡,而感染125的小鼠表现出轻微的症状并存活下来.
结论:
- H5N6 AIV 112,具有来自H9N2的内部基因,由于增强的致病性和传染性,对人类健康构成更大的潜在威胁.
- 对家禽中各种H5N6 AIV复合物的持续监测对于预防人类传播至关重要.
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