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针对癌症免疫治疗中的瘤相关巨细胞的纳米策略

Qian Li¹, Jingwei Xu^2,3, Runjia Hua⁴

¹Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, P. R. China.

Journal of Cancer

|April 30, 2025

概括

向与瘤相关的巨细胞 (TAMs) 是克服癌症免疫疗法耐药性的有希望的策略. 本综述探讨了通过关键信号通路调节TAM的纳米药物,以增强抗癌免疫力.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
纳米医学是一种纳米医学.

背景情况:

瘤相关巨细胞 (TAMs) 是丰富的免疫细胞,它们创造了一个免疫抑制的瘤微环境,导致免疫疗法耐药性.
向TAM是提高癌症免疫疗法的疗效的关键策略.

研究的目的:

提供针对TAMs的当前治疗策略的概述.
根据它们调节影响TAM的信号通路来对纳米药物进行分类.
讨论纳米药物在克服癌症免疫疗法耐药性的潜力.

主要方法:

对治疗策略的审查,包括阻止TAM招募,调节TAM两极化和直接消除TAM.
基于调制的信号通路 (NF-κB,HIF-1α,ROS,STAT,JNK,PI3K,Notch) 的纳米药物的分类.
讨论TAM调制纳米药物开发的最新进展.

主要成果:

纳米药物提供了针对TAM的多种方法,影响其两极分化和瘤微环境中的功能.
纳米药物对特定信号通路的调制是重编程TAM用于抗瘤作用的关键.
新兴的纳米药物显示出增强癌症免疫治疗结果的潜力.

结论:

通过纳米药物向TAM是一种可行的策略,可以改善癌症免疫治疗.
尽管临床转化和合成存在挑战,但纳米药物对癌症治疗具有重大前景.
对针对TAM信号通路的纳米药物进行进一步的研究是有必要的.

关键词:

癌症免疫疗法癌症免疫疗法在M1极化中,M1极化纳米药物是一种纳米药物.信号通道的信号通道.与瘤相关的巨细胞.

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