青少年时期的并发症预测了儿童时期出现的1型糖尿病的年轻人死亡率
Myra S Poon1,2, Albert K F Chan1, Janine M Cusumano1
1Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Pediatric diabetes
|April 30, 2025
概括
亚临床心脏自主神经功能障碍和1型糖尿病青少年的白蛋白分泌率升高预测了晚期死亡率. 与男性相比,女性的死亡风险明显高.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
背景情况:
- 1型糖尿病 (T1D) 的微血管并发症与心血管疾病和早期死亡有关.
- 了解青少年并发症对长期死亡率的影响对于T1D管理至关重要.
研究的目的:
- 调查青春期微血管并发症与T1D患者随后死亡率之间的关联.
- 识别特定的青少年并发症,预测死亡风险.
主要方法:
- 一组409名患有T1D的青少年被纵向跟踪了平均22.3年.
- 使用与澳大利亚国家死亡指数的数据链接来确定死亡率.
- 通用估计方程 (GEE) 分析了青少年并发症和死亡率之间的关联,计算了标准化死亡率 (SMR).
主要成果:
- 提升的白蛋白分泌率 (AER),瞳孔异常,缩血压SDS和心脏自主神经 (CAN) 异常预测死亡率.
- HbA1c水平不是死亡率的显著预测因素.
- 总体SMR为2.5,与男性 (2.1) 相比,女性 (3.5) 观察到的SMR更高.
结论:
- 自主神经病变 (CAN) 的亚临床标志物和青春期升高的AER预测T1D年轻成年人的死亡率.
- 与一般人群相比,女性的死亡风险较高,但男性的死亡风险较低.
- 血糖控制 (HbA1c) 没有被发现是这一队列中死亡率的显著预测因素.
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
471
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
471
Diabetes Mellitus: Overview and Type I Subtype
2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Carbohydrate Metabolism
10.5K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.5K
Psychoneuroimmunology: Diabetes and Cancer
16
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
16
Pathophysiology of Diabetes
805
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
805


