肺炎患者的凝血和炎症指标与静脉血栓栓塞:一个倾向-得分匹配研究
Yanhong Liu1, Bo Guo2, Zhen Meng1
1Department of Laboratory Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, People's Republic of China.
Journal of inflammation research
|April 30, 2025
概括
炎症和凝血标志物在患有静脉血栓塞栓症 (VTE) 的肺炎患者中升高. 监测这些指标可以帮助识别风险较高的VTE患者.
科学领域:
- 医学研究 医学研究
- 临床诊断 临床诊断 临床诊断
- 炎症和血栓形成的情况.
背景情况:
- 静脉血栓塞栓症 (VTE) 具有重大健康风险.
- 炎症越来越被认为是VTE发展的关键因素.
- 肺炎患者经常经历炎症反应,需要进行静脉瘤风险评估.
研究的目的:
- 在肺炎患者中调查炎症标志物和VTE之间的关系.
- 在这个队列中分析潜在的VTE生物标志物的实验室指标.
- 探索凝血和炎症标志物之间的相关性.
主要方法:
- 在2022年12月至2023年3月期间从肺炎患者收集的样本.
- 将患者分为VTE和非VTE组.
- 利用倾向性得分匹配 (PSM) 和测量凝血和炎症指标.
主要成果:
- 在静脉动脉突发症组中,D-二聚体,血-抗血复合物 (TAT),等离子体-α2-抗血复合物 (PIC),t-PA:PAI-1复合物 (tPAIC) 和血模块素 (TM) 的水平升高.
- 在VTE组中,白细胞计数 (WBC),中性粒细胞与淋巴细胞比率 (NLR),前素 (PCT) 和C反应蛋白 (CRP) 显著增加.
- 在炎症标记物 (WBC,NLR,CRP) 和凝血标记物 (D-二聚体,TAT,PIC,TM) 之间显示出显著的相关性.
结论:
- 肺炎患者表现出凝血和纤维溶解系统的激活.
- 肺炎中的VTE与炎症系统激活有关.
- 监测炎症和凝血指标有助于早期识别VTE风险.
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