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Songbiao Chen^1,2,3,4, Ke Shang^1,2,3, Ying Wei^1,2,3

¹Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.

Transboundary and emerging diseases

|April 30, 2025

概括

非洲猪瘟病毒 (ASFV) 严重影响了猪群. 本综述探讨了ASFV如何与cGAS-STING先天性免疫路径相互作用,详细介绍了病毒逃避策略和潜在的治疗点.

科学领域:

兽医病毒学兽医病毒学
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

非洲猪瘟病毒 (ASFV) 导致国内和野猪的严重疾病,死亡率高.
天生的免疫力,特别是cGAS-STING信号通路,对于宿主防御病毒感染至关重要.
ASFV已经发展出可以抵消宿主免疫反应的机制,包括cGAS-STING通路.

研究的目的:

审查了解ASFV感染与cGAS-STING通路之间的相互作用的最新进展.
阐明ASFV与cGAS-STING通路相互作用并回避的分子机制.
确定开发针对ASFV的新型疫苗和治疗方法的潜在途径.

主要方法:

关于ASFV病变发生和宿主-病原体相互作用的最近研究的文献综述.
在ASFV感染期间分析涉及cGAS-STING通路的分子机制.
对ASFV免疫逃避策略的当前知识的综合.

主要成果:

ASFV积极参与并操纵cGAS-STING通路.
ASFV采用各种策略来逃避cGAS-STING介导的免疫力,确保病毒的复制和生存.
了解这些相互作用,可以深入了解ASFV的病原性.

结论:

cGAS-STING通路是ASFV感染的关键战场.
针对ASFV对cGAS-STING通路的操纵,为疫苗和药物开发提供了有希望的战略.
对这些分子机制的进一步研究对于控制ASFV疫情至关重要.

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