2021年至2022年间,中国山东东部猫群中帕尔沃病毒的流行和分子进化情况
Jingyu Wang1,2, Zhirong Yan1, Haoran Liu1
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis and College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Transboundary and emerging diseases
|April 30, 2025
概括
猫类全白血病 (FPL) 在中国很普遍,在41.2%的患病猫中检测到帕沃病毒. 遗传分析显示,FPV-G1组占主导地位,这表明病毒进化和传播的增加.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 传染病的动态传染病的动态.
背景情况:
- 猫类泛白血病 (FPL),由猫类帕尔沃病毒 (FPV) 和狗类帕尔沃病毒2型 (CPV-2) 引起,对猫的健康构成重大威胁.
- 在中国,物猫种群的增加与FLP病例的增加有关.
- 了解帕沃病毒的流行率和遗传变异对于疾病控制至关重要.
研究的目的:
- 在中国山东东部的腹猫中调查帕沃病毒的流行率和遗传特征.
- 为了确定与其他病毒病原体共感染的帕尔沃病毒阳性猫.
- 分析FPV菌株的分子进化和家族遗传关系.
主要方法:
- 在2021-2022年期间,从51只腹猫收集了便样本.
- 聚合酶连锁反应 (PCR) 用于检测帕沃病毒和其他与猫科动物腹相关的病毒.
- 获取完整的VP2基因序列用于遗传学分析.
主要成果:
- 45.1%的样本检测出至少一种病毒病原体;帕尔沃病毒阳性为41.2% (21/51).
- 观察到高的同时感染率 (42.9%),主要是猫科冠状病毒 (FCoV),猫科天体病毒 (FAstV) 和猫科口腔病毒 (FBoV).
- 确定了20种FPV菌株和1种CPV-2c菌株 (亚洲原产,新进入该地区). 与A91S突变相关的占主导地位的FPV-G1组自2019年以来在中国占主导地位.
结论:
- 帕沃病毒在中国山东东部的腹猫中显示出高患病率和显著的同时感染率.
- FPV-G1组的出现和主导地位,以及特定的突变,突显了正在进行的病毒进化.
- 这项研究提供了对帕维病毒流行病学和演变的宝贵见解,有助于FPL诊断和治疗策略.
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