基于肌素和囊素C的方程之间产生不一致的结果,用于估计GFR
Pierre Delanaye1,2, Martin Flamant3, Emmanuelle Vidal-Petiot3
1Department of Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium.
Kidney international reports
|April 30, 2025
概括
从囊素C和肌氨酸中估计的不一致的球透率 (GFR) 是常见的. 欧洲功能联盟 (EKFC) 和重新表达的隆德-马尔默 (r-LMR) 方程被推用于CKD-EPI,以在不一致的情况下获得更好的准确性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床化学 临床化学
- 生物标志物研究 生物标志物研究
背景情况:
- 在估计膜过率 (GFR) 时,囊素C和肌素之间的不一致性构成了重大的临床挑战.
- 当这些标记物产生相互矛盾的结果时,估计GFR的最佳方程仍然不清楚.
- 准确的GFR估计对于诊断和管理病至关重要.
研究的目的:
- 用不同的方程 (CKD-EPI,EKFC,r-LMR) 评估不一致的GFR估计比例.
- 为了确定最准确的GFR估计方程对一致和不一致的结果.
- 为在临床实践中选择适当的GFR估计方法提供指导.
主要方法:
- 对15485名具有测量GFR (mGFR) 的参与者的横截面分析.
- 使用CKD-EPI,EKFC和r-LMR方程,从肌素 (eGFRcrea) 和囊素C (eGFRcys) 的GFR估计值进行比较.
- 基于绝对 (>15毫升/分钟/1.73米2) 或相对 (>20%) 差异的不一致性定义.
主要成果:
- 与EKFC (21.9-31.7%) 和r-LMR (22.8-32.8%) 相比,CKD-EPI方程式显示出不一致结果的比例较高 (35.1-40.6%).
- 对于EKFC和r-LMR方程,联合肌素和囊素C模型在不一致的情况下最准确地估计了mGFR.
- CKD-EPI方程对eGFRcys
结论:
- 与CKD-EPI相比,EKFC和r-LMR方程显示了较低的GFR估计不一致性.
- 这些方程与测量的GFR更好地一致,特别是在估计相矛盾的情况下.
- 建议使用EKFC和r-LMR,而不是CKD-EPI,以获得更可靠的GFR估计,特别是当结果不一致时.
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