在CKD内部:CKD跨国查的成本效益
Navdeep Tangri1, Kook-Hwan Oh2, Jason C J Choo3
1Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Kidney international reports
|April 30, 2025
概括
在全球范围内,对45岁及以上的成年人进行慢性病 (CKD) 查是具有成本效益的. 与目前的做法相比,2 eGFR和1 UACR"测试策略显著增加了CKD诊断率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
背景情况:
- 早期发现慢性病 (CKD) 对于减缓其进展至关重要,但许多患者在早期仍未被诊断出来.
- 目前的CKD查实践各不相同,可能导致错过诊断和延迟开始治疗.
研究的目的:
- 评估不同跨国CKD查策略的成本效益.
- 从付款人的角度来看,比较一般的查方法和高风险人群.
主要方法:
- 利用Inside CKD微型模拟模型在31个国家投影虚拟人口.
- 评估了查策略,包括"仅2个eGFR"和"2个eGFR和1个UACR"与当前实践相比.
- 包括一般人群 (≥45岁和≥65岁) 和高危子组 (2型糖尿病,高血压,心血管疾病).
主要成果:
- 使用2个eGFR和1个UACR进行的CKD查在所有研究国家的普通人口 (≥45岁) 中具有成本效益.
- "只有2个eGFR"战略在除一个国家以外的所有国家都具有成本效益.
- "2个eGFR和1个UACR"的策略显示出卓越的成本效益,并显著增加了CKD诊断率.
结论:
- 查CKD,特别是在45岁及以上的个体中,是全球成本有效的公共卫生策略.
- 这些发现支持全球指导方针,建议同时测试估计的淋巴细胞过率 (eGFR) 和尿动白蛋白与肌素比率 (UACR),同时考虑当地因素.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
30
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
30
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
53
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
53
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
45
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
45