在患有1型糖尿病的儿童中,纵向估计的淋巴细胞过率轨迹
Kristen Favel1,2,3,4, Cherry Mammen1,2, Constadina Panagiotopoulos1,5
1Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Pediatric diabetes
|April 30, 2025
概括
在患有1型糖尿病 (T1D) 的儿童中,定期监测功能至关重要. 许多患有T1D的儿童经历了功能下降,这突显了系统评估和跨学科护理的需要.
科学领域:
- 儿科脏病学 儿科脏病学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 患有1型糖尿病 (T1D) 的儿童有患糖尿病病 (DKD) 的风险.
- 目前的临床指导方针缺乏统一的建议,用于例行血清肌素 (SCr) 监测儿科T1D.
- 在这个人群中,诊断后功能变化的数据很少.
研究的目的:
- 描述T1D儿童估计的淋巴细胞过率 (eGFR) 轨迹.
- 在这个队列中确定降低EGFR,高血压和白蛋白尿的患病率.
- 检查功能参数和科推模式之间的关系.
主要方法:
- 从2016年12月到2019年2月,对307名患有T1D的儿童 (≤18岁) 进行了回顾性分析.
- 使用CKiD U25公式计算年化eGFR.
- 对eGFR轨迹 (下降,稳定,倾斜) 和eGFR水平 (正常,轻微下降,CKD) 的分类.
主要成果:
- 在平均2.3年的随访期间,33%的患者表现出eGFR轨迹的下降.
- 32%的人经历了轻微降低的EGFR,高血压或白膜尿;<10%的人被转诊科.
- 女性性别和更高的基线eGFR与eGFR轨迹下降有关.
结论:
- 患有T1D的儿童的功能并不均稳定,并且可以随着时间的推移而下降.
- 在儿科T1D中,支持对功能进行系统监测.
- 加强内分泌学和科之间的合作对于基于证据的护理至关重要.
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