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根据治疗方式的基础和玻尿酸胰岛素分布:来自SWEET糖尿病注册表的数据
Ferda Evin1, Sascha R Tittel2,3, Barbara Piccini4
1Division of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, Ege University, Izmir, Turkey.
Pediatric diabetes
|April 30, 2025
概括
在1型糖尿病 (T1D) 中最佳的基础胰岛素剂量因年龄和血糖控制而异,而不是糖尿病技术. 较低的基础和总每日胰岛素 (BD/TDD) 比率与小儿T1D患者较低的HbA1c相关.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病 技术 技术
背景情况:
- 在1型糖尿病 (T1D) 管理中的最佳基础胰岛素剂量仍然是争论的主题.
- 了解基础到总每日胰岛素剂量 (BD/TDD) 的变化对于儿童和青少年T1D治疗有效至关重要.
研究的目的:
- 研究患有T1D的儿科患者BD/TDD比率的可变性.
- 分析治疗方式 (每日多次注射[MDI]与持续皮下胰岛素输注[CSII]) 和糖尿病技术 (持续血糖监测[CGM]) 如何影响这一比例.
主要方法:
- 利用来自SWEET注册表的数据,包括38956名患有T1D的儿科患者.
- 根据MDI/CSII和CGM使用情况将患者分为四组.
- 分析了与年龄,性别,糖尿病持续时间,HbA1c,治疗方式和糖尿病技术相关的BD/TDD比率.
主要成果:
- 较低的BD/TDD比率与男性性别,年龄较小和较低的HbA1c显著相关.
- 在调整年龄,性别和糖尿病持续时间后,BD/TDD比率与不同糖尿病技术 (CGM和/或CSII) 之间没有发现显著的关联.
结论:
- 基础胰岛素相对于每日胰岛素总量较低的比例与T1D儿童的更好的血糖控制 (较低的HbA1c) 有关.
- 年龄和血糖控制是影响BD/TDD比率的关键因素,而糖尿病技术选择在这个队列中没有显著影响.
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