炎症性肠病老年患者的先进疗法:台湾的一项比较回顾性队列研究
Shih-Hua Lin1,2,3, Horng-Yih Chiu2, Chia-Jung Kuo2,3,4,5,6
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, New Taipei Municipal Tucheng Hospital, Tucheng, New Taipei City, Taiwan.
Therapeutics and clinical risk management
|April 30, 2025
概括
老年发病的炎症性肠病 (IBD) 患者表现出明显的特征和与年轻患者相比的治疗持久性. 针对这个不断增长的人口群体,定制的治疗策略是必不可少的.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 炎症性肠病 (IBD) 通常影响年轻人,但老年发病病例显著增加 (≥60岁).
- 与年轻人发病的IBD相比,老年人发病的IBD呈现出异常症状,感染和恶性瘤的风险增加.
- 老年IBD患者的药物持续性尚未得到充分研究,因此需要研究以优化治疗.
研究的目的:
- 研究和比较高级疗法在老年IBD患者和年轻IBD患者的持续时间.
- 确定与老年发病IBD相关的临床特征和结果.
- 分析老年IBD患者先进治疗持久性的预测因素.
主要方法:
- 在2017年10月至2023年9月接受先进治疗的511名IBD患者的回顾性队列研究.
- 分层分为老年发病 (≥60岁) 和对照 (<60岁) 组.
- 一年治疗持久性,感染,入院,并发症,手术和发作的比较;老年队列中先进治疗持久性的具体分析.
主要成果:
- 老年IBD患者 (n=107) 的BMI较高,性结肠炎较多,吸烟者较少,血细胞计数较低.
- 在老年发病和年轻发病IBD组之间,一年的临床结果,包括治疗持久性,是可比的.
- 在克罗恩病中,Infliximab和Ustekinumab显示出更高的一年持久性. 持续性预测因素包括蒙特利尔L1分类,乌斯提金巴使用和血红蛋白水平.
结论:
- 老年IBD患者表现出独特的临床特征和可比的先进治疗持久性,特别是在克罗恩病中.
- 这些发现强调了为老年IBD人口量身定制的治疗策略的需要.
- 对优化老年IBD患者治疗的进一步研究是有必要的.
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