肺结核复发的临床和实验室风险因素在三个合并的印度队列
Sonya Krishnan1,2, Nikhil Gupte2,3, Mandar Paradkar2,3
1Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Frontiers in tuberculosis
|April 30, 2025
概括
结核病的复发在治疗后很常见. 关键的风险因素包括两个月的积极培养,低BMI和男性性别,有助于风险患者的早期干预.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 药物敏感性肺结核 (PTB) 即使在成功治疗后也可能复发.
- 了解复发模式对于改善患者的治疗结果和预防疾病传播至关重要.
研究的目的:
- 确定结核病治疗完成后结核病复发的发病率和风险因素.
- 为管理高复发风险患者的临床策略提供信息.
主要方法:
- 从三个潜在的观察印度PTB队列中汇集了数据.
- 包括1164名14岁及以上的个人,他们已经完成了抗结核治疗.
- 评估了复发情况,并使用多变量逻辑回归来确定独立的风险因素.
主要成果:
- 复发发病率为每100人年8.5例 (95% CI 6.9-10.3),复发的中位时间为6个月.
- 95名 (8%) 个体经历了复发.
- 复发的独立风险因素包括第2个月的培养阳性 (aHR 2.06),BMI <17 kg/m2 (aHR 1.7) 和男性性别 (aHR 1.92).
结论:
- 2个月培养阳性,低BMI和男性性别是肺结核复发的重要独立风险因素.
- 在治疗期间和治疗后识别高风险个体可以指导有针对性的干预措施和加强监测策略.
- 这些发现可以帮助优化患者护理,以减少复发性结核病的负担.
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