加速度计测量体力活动与心血管疾病遗传风险的相互作用:英国生物银行的一项前性队列研究
Chaoyu Xu1,2, Qingrong Zhang1,2, Sihua Xu1,2
1Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
BMJ open sport & exercise medicine
|April 30, 2025
概括
定期体育活动,包括光强度活动,可以降低心血管疾病的风险. 运动的益处可能因个体的多基因风险评分 (PRS) 而有所不同.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传学和公共卫生
- 身体活动研究 身体活动研究
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 通过多基因风险评分 (PRS) 评估的遗传倾向会影响个体心血管疾病风险.
- 身体活动和遗传风险等生活方式因素之间的相互作用对于预防心血管疾病至关重要.
研究的目的:
- 研究体育活动和多基因风险评分 (PRS) 对心房动,冠心病 (CHD),高血压和缺血性中风风险的综合影响.
- 为了确定体力活动是否能在不同水平的遗传倾向中减轻心血管疾病风险.
主要方法:
- 利用了来自91,629名英国生物库参与者的数据,用加速度计测量身体活动.
- 量化总体体力活动 (TPA),中度至强度体力活动 (MVPA) 和轻强度体力活动 (LPA).
- 采用考克斯的比例危险模型来评估身体活动,PRS和心血管疾病结果之间的关联和相互作用.
主要成果:
- 所有测量的体力活动水平 (TPA,MVPA,LPA) 都与四种心血管疾病的风险降低有关,这在很大程度上与遗传风险无关.
- 观察到特定的相互作用,例如低PRS个体中LPA和心房动之间的U形关联,以及减弱的TPA-高血压风险与增加的遗传风险.
- 在高PRS个体中,不活动的可归因风险更高,在高PRS个体中观察到的CHD风险降低更大,这些人增加了MVPA.
结论:
- 增加体力活动,包括光强度活动,与较低患主要心血管疾病的风险有关.
- 身体活动带来的心血管健康益处的大小可以通过个体的基因风险概况来调节.
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