在术后抑郁症上术前乙胺的有效性:系统性审查和元分析
Hao-Yan Li1, Wen-Jing Xu1, Ya-Mei Wang1
1Department of Anesthesiology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Frontiers in psychiatry
|April 30, 2025
概括
素有效地减少了手术后抑郁症 (POD) 在各种随访期间的发生率和严重程度. 需要进行进一步的研究,以优化剂量和减轻术后使用的潜在不良影响.
科学领域:
- 麻醉学和外科手术期间的医学.
- 精神病学和心理健康 精神病学和心理健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后抑郁症 (POD) 是一种严重的并发症,影响手术患者的治疗结果和医疗费用.
- 作为NMDA受体对抗剂的埃斯凯特胺显示出快速抗抑郁作用的前景,但其外科手术期间的作用尚未得到充分研究.
- 进行了一项系统性审查和元分析,以评估埃斯基坦胺在治疗POD中的有效性.
研究的目的:
- 评估胺在减少术后抑郁症的发病率和严重性的有效性.
- 调查埃斯基坦胺对POD得分和发病率的短期和长期影响.
- 为了告知应用的外科手术期间止痛药和抗抑郁药的联合治疗.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了主要的数据库,包括PubMed,科克兰图书馆,科学网和Medline.
- 使用Review Manager 5.3分析的数据,包括8个与1724名患者进行的RCT.
主要成果:
- 与对照组相比,sketamine显著减少了POD.
- 在1周 (RD -0.09),2周 (RD -0.08) 和长期随访 (RD -0.06) 观察到POD的改善.
- 在所有随访期内,统计学意义保持不变 (P < 0.0001 至 P = 0.0002).
结论:
- 素在减少POD发病率和严重程度方面表现出有效性.
- 与埃斯基坦胺相关的不良影响需要进一步调查.
- 优化剂量方案和探索多模式策略对于安全有效的术后使用至关重要.
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