在帕金森病中,大脑结构和结构共变网络的变化与发病的不同方面
Tianqi Xu1, Zhihuai Deng1, Yinhui Yu1
1Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in aging neuroscience
|April 30, 2025
概括
与右发病患者相比,左发病 (LPD) 的帕金森病 (PD) 患者在特定的大脑区域的皮质表面积减少. 网络分析揭示了LPD中明显的拓差异,为PD症状横向化提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 脑部成像 脑部成像
背景情况:
- 帕金森病 (PD) 通常表现出单边运动症状,在发病方面严重程度更大.
- 大脑结构和网络的改变可能是PD观察到的运动不对称的基础.
研究的目的:
- 为了研究左发性PD (LPD) 和右发性PD (RPD) 患者之间的结构性大脑差异.
- 分析LPD与RPD中的结构共变网络 (SCN),以了解网络拓变化.
主要方法:
- 招募了51名LPD和49名RPD患者进行临床评估和3T结构MRI.
- 在皮层表面积 (CSA) 和厚度 (CT) 分析中采用基于表面的形态测量 (SBM).
- 利用大脑连接工具箱来构建和分析结构共变性网络 (SCN).
主要成果:
- 与LPD患者相比,与RPD患者相比,LPD患者在右上边缘,右前,左下侧叶和左舌头中显示出CSA的减少.
- 在LPD和RPD组之间没有发现皮质厚度的显著差异.
- 在LPD患者表现出改变的SCN拓,包括增加特征路径长度和减少基于CSA的网络中的小世界指数.
结论:
- 在LPD的特定区域减少CSA可能与诸如认知障碍之类的非运动症状有关.
- 在LPD和RPD之间的SCN显著的全球拓差异表明不同的网络组织.
- 这些发现为帕金森病症状横向化的神经机制提供了新的见解.
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