身体质量指数和肉类与骨质疏松症的关联:用于风险评估的预测性诺莫格拉姆模型
Qingling Liu1, Shengquan Pan2, Ming Tang3,4
1Department of Gastroenterology and Endocrinology, Huining County People's Hospital, Huining County, Gansu Province, China.
Therapeutic advances in endocrinology and metabolism
|April 30, 2025
概括
下肢体质量指数 (BMI) 和非肉类是对骨质疏松症的保护. 皮症显著调解了BMI和骨质疏松症风险之间的关系,名谱显示出良好的预测价值.
科学领域:
- 老年学是一门学科.
- 代谢障碍 代谢障碍 代谢障碍
- 骨健康 骨健康 骨健康
背景情况:
- 骨质疏松症是一个重大的健康问题,特别是在老龄化人口中.
- 体重指数 (BMI) 和肉是已知的骨质疏松症风险因素,但它们的相互关系尚未完全理解.
- 澄清肉类症在调解BMI对骨质疏松症影响中的作用对于开发有效的预防和治疗策略至关重要.
研究的目的:
- 为了研究BMI,肉症和骨质疏松症之间的关联.
- 探索结合生化标志物的骨质疏松症的预测价值.
- 为了检查 sarcopenia 在BMI 和骨质疏松症之间的关系中介作用.
主要方法:
- 对813名住院患者的临床数据进行了回顾性分析.
- 调解分析以评估BMI,肉症和骨质疏松症之间的关联.
- 使用后勤回归和最小绝对收缩和选择运算符 (LASSO) 开发和验证一个名ogram模型,通过ROC曲线,校准曲线,DCA和CIC进行评估.
主要成果:
- 体重指数和骨肌肉质量与血清25-氧维生素D和有负相关性.
- 体重指数<28和非肉类的结合被确定为对骨质疏松症的保护因素.
- 在BMI和骨质疏松症之间的关联中,皮症显著介导了46.88%.
- 性别,年龄,HDL,性酸酶,BMI和肉是骨质疏松症的独立预测因子,名谱达到0.859 (训练) 和0.866 (测试) 的AUC.
结论:
- 较低的BMI和缺乏肉症与骨质疏松症风险降低有关.
- 开发的诺米图表显示了强大的骨质疏松症预测能力.
- 这项研究强调了BMI和肉症对骨质疏松症的显著负预测价值.
相关概念视频
Bone Disorders
3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K
Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
What is the Skeletal System?
51.9K
Overview
51.9K


