基于纳米材料的药物输送系统针对功能性细胞治疗骨关节炎:机制,挑战和未来前景
Hui Kong1,2, Qijun He2, Juanjuan Han2
1College of Exercise and Health, Shanghai University of Sport, Shanghai, People's Republic of China.
International journal of nanomedicine
|April 30, 2025
概括
本综述探讨了用于骨关节炎 (OA) 治疗的基于纳米材料的药物递送系统 (DDS). 它详细介绍了如何将功能细胞设计为DDS,作为标或箭头来对抗OA的进展.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 类风湿病学 类风湿病学
背景情况:
- 骨关节炎 (OA) 是一种慢性关节疾病,涉及软骨退化和炎症.
- 在OA中,关键的功能性细胞,包括巨细胞和软质细胞,通过细胞因子和外体相互作用.
- 目前的OA治疗方法往往缺乏向性治疗,因此需要新的治疗策略.
研究的目的:
- 审查用于骨关节炎 (OA) 治疗的基于纳米材料的药物递送系统 (DDS) 的进展.
- 阐明功能细胞被设计成OA治疗的DDS的机制.
- 提供全面的研究进展和针对OA功能细胞的治疗策略的综述.
主要方法:
- 对基于纳米材料的DDS针对OA中的功能细胞的研究的文献综述.
- 分析涉及连接物改性纳米材料和细胞膜/细胞外囊泡伪装DDS的机制.
- 综合有关功能细胞作为治疗点和药物输送载体的信息.
主要成果:
- 基于纳米材料的DDS可以通过表面连接体或细胞膜遮来向OA功能细胞.
- 功能性细胞可以被设计成"箭头"或"目标",用于精确的OA药物输送.
- 这种方法通过调节细胞相互作用,为OA治疗提供了一个新的策略.
结论:
- 针对功能细胞的基于纳米材料的DDS在OA治疗中是一个有前途的前沿.
- 将功能细胞工程化为DDS提供了双重准和交付机制.
- 本次审查巩固了当前的知识,并为OA管理提出了新的途径.
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