从多个角度评估咖啡消费对心脏结构和功能的影响
Xiong-Bin Ma1, Yan-Lin Lv1, Lin Qian1
1The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Frontiers in cardiovascular medicine
|April 30, 2025
概括
咖啡消费可能有助于预防老年欧洲人与年龄相关的心脏体积损失. 遗传分析表明,它通过血压和体重影响心脏结构,可能提供心脏保护.
科学领域:
- 心血管遗传学 心血管遗传学
- 营养流行病学 营养流行病学
- 老年学是一门学科.
背景情况:
- 与年龄有关的心脏缩是老年人群的一个重大问题.
- 了解咖啡饮用等生活方式因素对心脏结构的影响,对于预防性健康策略至关重要.
研究的目的:
- 在欧洲老年人群中调查咖啡消费与心脏结构和功能之间的因果关系.
- 通过先进的遗传方法来探索潜在的基因机制,以这种关联为基础.
主要方法:
- 分析了来自欧洲老年人的全基因组关联研究 (GWAS) 数据.
- 使用了链接不平衡得分回归 (LDSC),双步门德尔随机化 (MR) 和同位分析.
- 进行了敏感性分析,以确保调查结果的可靠性.
主要成果:
- LDSC揭示了咖啡消费与心脏参数 (不包括LV和RV射出分数) 之间的积极遗传相关性.
- MR 分析表明了有利的关联,咖啡摄入量增加与更大的心室体积有关 (LV 终止-透气/终止-静脉,RV 终止-透气/中风体积).
- 调解分析显示,咖啡消费与下降的透静血压和升高的BMI相关,这反过来又影响了心脏参数.
结论:
- 在老年欧洲人中,基因预测的咖啡消费可能会减轻与年龄相关的心室体积损失.
- 这种效应似乎是由减小的透气血压和增加的BMI调节的,这表明潜在的心脏保护机制对心脏缩.
- 将咖啡消费纳入心血管风险评估和个性化建议是有必要的.
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