上肢外周神经超声波,作为对肌缩侧面硬化症的诊断辅助
Keivan Basiri1,2, Hanieh Paydari1,3, Fatemeh Abbasi4
1Department of Neurology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Advanced biomedical research
|April 30, 2025
概括
上肢神经的超声扫描显示,在肌缩侧硬化症 (ALS) 患者中,近端中枢神经截面面积 (CSA) 减少. 这一发现可能有助于诊断ALS,尽管其他神经测量需要进一步调查.
科学领域:
- 神经学 神经学
- 医疗成像医学成像
- 周围神经疾病 周围神经疾病
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种渐进的运动神经元疾病,由于缺乏特定的诊断标志物,具有诊断挑战.
- 目前对ALS的诊断方法可能是复杂和耗时的.
研究的目的:
- 评估上肢外围神经超声波在检测肌缩侧面硬化症 (ALS) 的实用性.
- 评估外围神经横截面积 (CSA) 测量是否可以区分ALS患者与健康对照.
主要方法:
- 一项涉及30名ALS患者和30名年龄/性别匹配的健康对照的病例控制研究.
- 超声波用于测量上肢中介和部神经的近端和远端截面区域 (CSA).
- 进行了接收器操作曲线 (ROC) 分析,以确定诊断ALS相关的外围神经变化的潜在切断点.
主要成果:
- 与对照组相比,ALS患者的近端中枢神经CSA和近端至远端比率在两个上肢显著降低 (P <0.05).
- 距离中枢神经CSA在不同组之间没有显著差异.
- 在ALS患者中观察到右手的下偏斜椎神经CSA (P = 0.007) 和左手的近端椎神经CSA (P = 0.001),但其他椎神经测量显示没有显著差异.
- 根据评估的神经测量,没有确定任何重要的切断点,以可靠地区分ALS患者与健康对照群.
结论:
- 肘穴中的近端中枢神经CSA显示出作为ALS有价值的诊断指标的潜力.
- 远端中枢神经的诊断价值和ALS的部神经测量的所有部分需要进一步调查,并仍在争论中.
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