甘油三/高密度脂蛋白-胆固醇比率在预测美国成年人之间代谢功能障碍相关的脂肪性肝病时优于传统的脂质指标
Jin Yuan1, Xuequan He1, Yan Lu1
1Puer Hospital of Traditional Chinese Medicine, Puer, China.
Frontiers in endocrinology
|April 30, 2025
概括
高血糖与高血糖-c比率 (TG/HDL-c) 是代谢功能障碍相关的脂肪性肝病 (MASLD) 的强有力的预测指标,其表现优于单个标志物. 保持健康的脂质水平可能会降低MASLD风险.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 肝病学 肝病学是一种肝病学.
背景情况:
- 三糖化物 (TG),高密度脂蛋白胆固醇 (HDL-c) 和它们的比例 (TG/HDL-c) 是与代谢功能障碍相关的关键脂质标记物.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题,具有重大临床影响.
研究的目的:
- 调查TG,HDL-c和TG/HDL-c比率与MASLD之间的关联.
- 为了确定TG/HDL-c比率是否为MASLD提供了比单独的TG或HDL-c更好的预测能力.
主要方法:
- 使用NHANES 2017-2020数据库进行的横截面研究.
- 进行了单变量和多变量逻辑回归分析来评估关联.
- 接收器运行特征 (ROC) 曲线分析评估了预测效率.
主要成果:
- TG,HDL-c和TG/HDL-c比均与MASLD有显著的相关性 (p <0.05).
- 该TG/HDL-c比率显示了最高的预测值 (AUC = 0.732),超过了TG (AUC = 0.713) 和HDL-c (AUC = 0.313).
- 仅HDL-c的预测能力有限可能源于其在脂质代谢中的复杂作用.
结论:
- 良好的TG,HDL-c和TG/HDL-c水平可以降低患MASLD的风险.
- 将TG/HDL-c比率纳入预测模型可以提高准确性,而不是单独使用TG或HDL-c.
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