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一个新的三重重组H3N8禽流感病毒:特征,致病性和传染性

Sheng Chen^1,2,3,4,5, Shuqun Shen^1,6, Yutao Teng^1,2

¹Heyuan Branch, Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

Transboundary and emerging diseases

|April 30, 2025

概括

一种新的禽流感H3N8病毒 (GD-H3N8) 在中国被分离出来. 这种重组病毒表现出哺乳动物适应性突变,并在人类细胞和小鼠中有效复制,突出显示了潜在的动物感染风险.

科学领域:

病毒学病毒学
动物传播疾病动物传播疾病
公共卫生公共卫生

背景情况:

禽流感病毒 (AIV) 随着人类感染的增加而构成越来越大的威胁.
像H3N2,H5N1,H7N9和H10N8这样的亚型是已知的人类病原体.
流行H3N8 AIVs的遗传和生物特征仍然不完全理解.

研究的目的:

来自中国的新型三重重组型H3N8禽流感病毒的分离和鉴定.
为了研究已分离的GD-H3N8病毒的遗传构成,哺乳动物的适应潜力和复制能力.

主要方法:

从中国广东的群中分离出一种新型H3N8病毒 (GD-H3N8).
基因分析以确定基因起源和重组模式.
在鸟类,哺乳动物和人类细胞系中进行体外生长动力学测试.
在小鼠和身上进行体内研究,以评估复制,感染和传播.

主要成果:

一种新型的三重重组型H3N8病毒 (GD-H3N8) 被分离出来,具有欧亚H3,北美N8和H9N2内部基因.
GD-H3N8病毒与人类H3N8菌株具有很高的同源性,并具有哺乳动物适应性突变.
在鸟类,哺乳动物和人类细胞中观察到有效的复制 in vitro.
该病毒在没有预先适应的情况下在小鼠中有效复制,并在中引起全身感染和传播.

结论:

新型禽流感病毒GD-H3N8显示了哺乳动物适应和动物传播的巨大潜力.
调查结果强调,迫切需要对H3N8 AIV进行持续监测.
持续监测对于检测潜在的流行病菌株和保护公共健康至关重要.

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