在一个密集农场中对NADC34类菌株的长度研究揭示了不同的进化
Sijia Xu1,2,3, Jing Liu1,2,3, Jiabao Xing1,2,3
1Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Transboundary and emerging diseases
|April 30, 2025
概括
中国的NADC34类猪生殖和呼吸道病毒 (PRRSV) 菌株的进化显示出复杂的重组和不同的致病性. 持续的农场监测揭示了病毒演变的变化和小猪中二次感染的增加,影响了疾病控制策略.
科学领域:
- 兽医病毒学 兽医病毒学
- 动物流行病学动物流行病学
- 分子进化分子进化
背景情况:
- 猪生殖和呼吸系统病毒 (PRRSV) 对全球猪业产生重大影响.
- 了解强化农业中类似NADC34的PRRSV菌株的进化和致病性至关重要.
- 在单一农场连续爆发期间的生物变异仍然不太清楚.
研究的目的:
- 研究类似NADC34的PRRSV菌株的进化特征和病原性.
- 在密集型养殖系统中分析PRRSV连续爆发的变化.
- 识别改变病原性和二次感染的潜在促成因素.
主要方法:
- 在密集养猪场进行PRRSV持续监测.
- 两种PRRSV菌株 (GDHZ109/2020和GDYS162/2022) 的隔离和全基因组测序.
- 遗传学,重组和致病性分析;呼吸道微生物多样性的评估.
主要成果:
- 两个类似NADC34的PRRSV菌株,GDHZ109/2020和GDYS162/2022,被分离和测序,共享96.5%的同源性.
- 这两种菌株都属于1.8系 (NADC30代表),复杂的重组模式涉及多个PRRSV菌株.
- 与GDYS162/2022相比,GDHZ109/2020在小猪中表现出更高的致病性和死亡率,与Klebsiella等机会性病原体增加有关.
结论:
- 类似NADC34的复合PRRSV菌株在密集养殖场内动态演变,可能改变病原性.
- 观察到的致病性变化和二次感染增加凸显了适应性疾病控制策略的必要性.
- 这项研究增强了对PRRSV流行和演变的理解,为预防和控制措施提供了信息.
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