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关于动物感染的CRISPR/基于案例的策略的进展

Yi Zhang^1,2, Qifeng Peng^1,2, Renjun Zhang³

¹Institute of Zoonosis, College of Public Health, Zunyi Medical University, Zunyi, China.

Transboundary and emerging diseases

|April 30, 2025

概括

聚类定期间隔的短平行体重复 (CRISPR) /与CRISPR相关的 (Cas) 基因编辑提供了高效和成本效益的动物性疾病研究. 本综述探讨了CRISPR/Cas的应用,局限性以及预防和治疗动物病的未来潜力.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
传染性疾病传染性疾病

背景情况:

集群定期间隔的短平行体重复 (CRISPR) /与CRISPR相关的 (Cas) 是一个领先的基因编辑技术.
克里斯普尔/卡斯在动物传染病研究中具有广泛的应用.

研究的目的:

审查CRISPR/Cas原则和在动物传染病中的应用.
分析CRISPR/Cas在动物传染病控制中的当前局限性和未来前景.
促进CRISPR/Cas技术的改进,以预防和治疗动物病.

主要方法:

关于CRISPR/Cas原则的文献审查.
在畜生病研究中分析CRISPR/Cas应用.
评估CRISPR/Cas技术的优点,弱点和未来方向.

主要成果:

在基因编辑方面,CRISPR/Cas技术非常高效且具有成本效益.
在将CRISPR/Cas应用于动物病的各个方面方面取得了显著进展.
目前的局限性阻碍了广泛应用,需要进一步开发.

结论:

克里斯普尔/卡斯对推进动物传染病诊断,疫苗和了解病变发生有很大的前景.
进一步完善CRISPR/Cas技术将增强其在动物传染病预防和控制中的作用.
基于CRISPR/Cas的策略预计将大大帮助全球打击动物传播疾病的努力.

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