在常见型COVID-19中形态大脑网络和认知功能的纵向变化:为期3个月的随访研究
Ying Liu1,2, Bei Peng2, Haixia Qin2
1Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Frontiers in neurology
|April 30, 2025
概括
常见型冠状病毒病 (COVID-19) 暂时破坏与认知相关的大脑网络. 皮下网络显示连接性增加,一些网络随着时间的推移而得到改善,这表明大脑可塑性和认知恢复的潜力.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 常见型冠状病毒病 (COVID-19) 可能会影响神经功能.
- 了解大脑的形态网络变化和COVID-19后的认知恢复至关重要.
研究的目的:
- 在急性COVID-19中调查形态大脑网络和认知功能.
- 在3个月的随访期内检查这些网络和功能中的动态变化.
主要方法:
- 对COVID-19患者和对照进行了高分辨率T1加权成像和认知评估.
- 形态大脑网络是使用灰色物质体积相似性来构建的,并用图形理论来分析.
- 统计分析包括独立和配对的样本t测试与错误发现率纠正.
主要成果:
- 急性COVID-19显示皮下网络 (SCN) 连接性增加,前端双层网络 (FPN) - 边缘网络 (LN) 连接性减少.
- 在3个月的随访中,SCN连接仍然很高,一些网络的部分恢复和FPN-LN显著改善.
- 认知得分,包括数字符号替换和口头流利性测试,随着时间的推移而得到改善.
结论:
- COVID-19导致与认知相关的大脑网络的短期干扰,皮质下网络表现出补偿性变化.
- 网络连接的部分恢复和改善的认知功能突出显示了大脑的可塑性.
- 前端对象网络与边缘网络的连接性可以作为COVID-19患者认知恢复的神经成像标记.
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